Gr1+ Macrophages and Dendritic Cells Dominate the Inflammatory Infiltrate 12 h After Experimental Intracerebral Hemorrhage
نویسندگان
چکیده
منابع مشابه
Simvastatin and atorvastatin improve neurological outcome after experimental intracerebral hemorrhage.
BACKGROUND AND PURPOSE This study investigates the effects of statin treatment on experimental intracerebral hemorrhage (ICH) using behavioral, histological, and MRI measures of recovery. METHODS Primary ICH was induced in rats. Simvastatin (2 mg/kg), atorvastatin (2 mg/kg), or phosphate-buffered saline (n=6 per group) was given daily for 1 week. MRI studies were performed 2 to 3 days before ...
متن کاملNeuroinflammation after intracerebral hemorrhage
Spontaneous intracerebral hemorrhage (ICH) is a particularly severe type of stroke for which no specific treatment has been established yet. Although preclinical models of ICH have substantial methodological limitations, important insight into the pathophysiology has been gained. Mounting evidence suggests an important contribution of inflammatory mechanisms to brain damage and potential repair...
متن کاملHMG-CoA reductase inhibitor, atorvastatin, promotes sensorimotor recovery, suppressing acute inflammatory reaction after experimental intracerebral hemorrhage.
BACKGROUND AND PURPOSE Statins have neuroprotective effects on ischemic stroke. They modify the endothelial function, increase blood flow, and inhibit thrombus formation, which are independent of lipid-lowering effects. However, whether statins have a protective effect toward hemorrhagic stroke is yet unknown. To test this possibility, we attempted to determine the effect of atorvastatin on exp...
متن کاملHematoma Changes During Clot Resolution After Experimental Intracerebral Hemorrhage.
BACKGROUND AND PURPOSE Hematoma clearance occurs in the days after intracerebral hemorrhage (ICH) and has not been well studied. In the current study, we examined changes in the hematoma in a piglet ICH model. The effect of deferoxamine on hematoma was also examined. METHODS The ICH model was induced by an injection of autologous blood into the right frontal lobe of piglets. First, a natural ...
متن کاملAcute Statin Treatment Improves Recovery after Experimental Intracerebral Hemorrhage.
BACKGROUND AND PURPOSE We have previously demonstrated that 2-week treatment of experimental intracerebral hemorrhage (ICH) with a daily dose of 2 mg/kg statin starting 24 hours post-injury exerts a neuroprotective effect. The present study extends our previous investigation and tests the effect of acute high-dose (within 24 hours) statin therapy on experimental ICH. MATERIAL AND METHODS Fift...
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ژورنال
عنوان ژورنال: Translational Stroke Research
سال: 2012
ISSN: 1868-4483,1868-601X
DOI: 10.1007/s12975-012-0174-9